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RGD-Modified Nanocarrier-Mediated Targeted Delivery of HIF-1α-AA Plasmid DNA to Cerebrovascular Endothelial Cells for Ischemic Stroke Treatment

Katie

Research have proven that the usage of proangiogenic genes can enhance the prognosis of ischemic stroke by selling angiogenesis on the harm web site. For instance, inside this research, hypoxia-inducible issue 1-α (HIF-1α) has exhibited an angiogenic impact. Our earlier research reported a extra steady HIF-1α mutant kind (HIF-1α-AA), which was transfected into mesenchymal stem cells to offer neuroprotective results towards ischemic stroke. The security of nonviral gene vectors has attracted researchers’ consideration.

This research encapsulated the HIF-1α-AA plasmid DNA right into a newly synthesized efficient nonviral gene vector, a hyperbranched cationic amylopectin by-product (DMAPA-Amyp) nanocarrier. As well as, a focusing on technique was utilized to pick the RGD peptides and bind to the designed nanocarrier as a molecule focusing on endothelial cells. The focusing on technique is used to instantly ship the nanocarriers to the vascular endothelial cells of the mind peri-infarct web site.

This research emphasizes the focusing on potential of nanocarrier and its therapeutic impact on cerebral ischemia. The outcomes confirmed that RGD-DMAPA-Amyp had good biocompatibility and a excessive cell uptake charge, indicating that it’s a protected nonviral gene vector that may be endocytosed by human cells. In rat fashions of ischemic stroke, in contrast with the nontargeted nanocarrier group, extra RGD-DMAPA-Amyp nanoparticles aggregated in vascular endothelial cells of the peri-infarct area and considerably improved the restoration of neurological perform.

It’s indicated that the RGD-modified nanomedicine promotes the restoration of nerve perform extra effectively. Additional research on the mechanism of RGD-DMAPA-Amyp/HIF-1α-AA within the therapy of cerebral ischemia displayed potential to considerably promote the formation of recent blood vessels in vivo. Our findings recommend that the RGD-modified nonviral gene vector containing HIF-1α-AA seems to be a protected and promising therapeutic technique for ischemic stroke gene remedy.

RGD-Modified Nanocarrier-Mediated Targeted Delivery of HIF-1α-AA Plasmid DNA to Cerebrovascular Endothelial Cells for Ischemic Stroke Treatment

Base and Nucleotide Excision Restore Pathways in DNA Plasmids Harboring Oxidatively Generated Guanine Lesions

The bottom and nucleotide excision restore pathways (BER and NER, respectively) are two main mechanisms that take away DNA lesions shaped by the reactions of genotoxic intermediates with mobile DNA. Now we have demonstrated earlier that the oxidatively generated guanine lesions spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) are excised from double-stranded DNA by competing BER and NER in whole-cell extracts [Shafirovich, V., et al. (2016) <i>J. Biol. Chem</i>. <b>321</b>, 5309-5319]. On this work we in contrast the NER and BER yields with single Gh or Sp lesions embedded on the identical websites in covalently closed round pUC19NN plasmid DNA (cccDNA) and in the identical however linearized kind (linDNA) of this plasmid.

The kinetics of the Sp and Gh BER and NER incisions have been monitored in HeLa cell extracts. The yield of NER merchandise is ∼5 occasions higher in covalently closed round DNA than within the linearized kind, whereas the BER yield is smaller by ∼20-30% relying on the guanine lesion. Management BER experiments with 8-oxo-7,8-dihydroguanine (8-oxoG) present that the BER yield is elevated by an element of only one.4 ± 0.2 in cccDNA relative to linDNA. These stunning variations in BER and NER actions are mentioned by way of the shortage of termini in covalently closed round DNA and the DNA lesion search dynamics of the NER DNA injury sensor XPC-RAD23B and the BER enzyme OGG1 that acknowledges and excises 8-oxoG.

Regeneration of Paralyzed Vocal Fold by the Injection of Plasmid DNA Complicated-Loaded Hydrogel Bulking Agent

Varied progress issue supply methods have been used within the therapy of glottal insufficiency; nevertheless, comparatively little consideration has been paid to a gene supply system for elements of energetic vocal fold (VF) regeneration. Herein, we current a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) combination hydrogel dispersed with polycaprolactone (PCL) microspheres that may improve simultaneous regeneration of VF muscle and lamina propria, in addition to have a bulking impact on atrophied VF.

Now we have demonstrated long-term efficacy of bFGF synthesized from pDNA complex-transfected cells in vitro. PCL microspheres-dispersed ALG/HA hydrogel (with or with out pDNA complicated loading) are injected into rabbit VFs with recurrent laryngeal nerve denervation. The PCL microspheres dispersed within the hydrogel bulking brokers stay steady on the utilized web site, resulting in fixed medialization of the paralyzed VF with out vital preliminary quantity loss even after 24 weeks.

A regenerative impact for collagen deposition and HA synthesis across the injected web site, that are main parts of VF tissue, is effectively confirmed within the pDNA-complex-loaded hydrogel group. Furthermore, the compensation of atrophied VFs additionally results in the contact of bilateral VF and the exceptional restoration of voice perform within the pDNA-complex-loaded group.

Propane Transfer System
M-CEM-37015 1 UNIT
EUR 688
Description: Propane Transfer System

Thermal Transfer Ribbon
HIS3233 EACH
EUR 181.2

Transfer Rack 0.5 mL
E3880000305 EACH
EUR 52.8

Rat cholest erolester transfer protein/lipid transfer protein ELISA kit
E02C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat cholest erolester transfer protein/lipid transfer protein ELISA kit
E02C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat cholest erolester transfer protein/lipid transfer protein ELISA kit
E02C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat cholest erolester transfer protein/lipid transfer protein ELISA kit
E06C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat cholest erolester transfer protein/lipid transfer protein ELISA kit
E06C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat cholest erolester transfer protein/lipid transfer protein ELISA kit
E06C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog cholest erolester transfer protein/lipid transfer protein ELISA kit
E08C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog cholest erolester transfer protein/lipid transfer protein ELISA kit
E08C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog cholest erolester transfer protein/lipid transfer protein ELISA kit
E08C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E07C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E07C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E07C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human cholest erolester transfer protein/lipid transfer protein ELISA kit
E01C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human cholest erolester transfer protein/lipid transfer protein ELISA kit
E01C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human cholest erolester transfer protein/lipid transfer protein ELISA kit
E01C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit
E03C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit
E03C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse cholest erolester transfer protein/lipid transfer protein ELISA kit
E03C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit
E04C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit
E04C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit cholest erolester transfer protein/lipid transfer protein ELISA kit
E04C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit
E09C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit
E09C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey cholest erolester transfer protein/lipid transfer protein ELISA kit
E09C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

SPINE Puck Transfer Tool
M-SP-PTT-1 1 UNIT
EUR 386
Description: SPINE Puck Transfer Tool

Phospholipid transfer Antibody
20-abx110096
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Transfer Rack 1.5/2.0 mL
E3880000151 EACH
EUR 49.2

Guinea pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E05C0732-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E05C0732-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig cholest erolester transfer protein/lipid transfer protein ELISA kit
E05C0732-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig cholest erolester transfer protein/lipid transfer protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

6400 Thermal Transfer Ribbon
804777 EACH
EUR 45.72

SSRL Cassette Transfer Handle
M-CP-111-003 1 UNIT
EUR 460
Description: SSRL Cassette Transfer Handle

Human cholest erolester transfer protein/lipid transfer protein,CETP/LTP ELISA Kit
201-12-1516 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human cholest erolester transfer protein/lipid transfer protein(CETP/LTP)ELISA Kit
GA-E1532HM-48T 48T
EUR 346.8

Human cholest erolester transfer protein/lipid transfer protein(CETP/LTP)ELISA Kit
GA-E1532HM-96T 96T
EUR 559.2

Human cholest erolester transfer protein/lipid transfer protein(CETP/LTP)ELISA Kit
QY-E03917 96T
EUR 433.2

Human cholest erolester transfer protein/lipid transfer protein,CETP/LTP ELISA Kit
YLA0018HU-48T 48T
EUR 435

Human cholest erolester transfer protein/lipid transfer protein,CETP/LTP ELISA Kit
YLA0018HU-96T 96T
EUR 562.5

Recombinant Bovine Glycolipid transfer protein Protein, His-SUMO, E.coli-10ug
QP6098-ec-10ug 10ug
EUR 391.2

Cryo Transfer Face for SEM
M-CEM-37000-S 1 UNIT
EUR 3295
Description: Cryo Transfer Face for SEM

Cryo Transfer Face for TEM
M-CEM-37000-T 1 UNIT
EUR 3185
Description: Cryo Transfer Face for TEM

Phospholipid transfer Antibody (HRP)
20-abx108612
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Thermal Transfer Ribbon 1x2.7 OD
HIS3524 EACH
EUR 244.8

Phospholipid transfer Antibody (FITC)
20-abx107192
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Laboratory Thermal Transfer Printer
BAL4730 EACH
EUR 1458

Human Transfer factor ELISA Kit
ELA-E1333h 96 Tests
EUR 988.8

BioPhotometer data transfer software
E6132854007 EACH
EUR 464.4

Transfer Pipette 15mL Large Bulb
ARG1836 PK250
EUR 34.34

Xpert Native Transfer Buffer(10X)
P9001-050 500ml
EUR 111.6

Xpert Native Transfer Buffer(10X)
P9001-100 1L
EUR 165.6

Phospholipid transfer Antibody (Biotin)
20-abx105774
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

PAGE Gel Transfer Buffer, 10 x
GR103018 1 L
EUR 79

Recombinant Human Alpha-tocopherol transfer protein Protein, His-SUMO, E.coli-10ug
QP6847-ec-10ug 10ug
EUR 326.4

Phospholipid transfer Polyclonal Antibody
42297-100ul 100ul
EUR 399.6

SuperBlot Western Transfer buffer 10X
DG-WEST 500ml
EUR 136.56

Human Transfer factor,TF ELISA Kit
201-12-1733 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Transfer factor,TF ELISA Kit
CN-04584H1 96T
EUR 520.8

Human Transfer factor,TF ELISA Kit
CN-04584H2 48T
EUR 340.8

Human Transfer factor(TF)ELISA Kit
GA-E1749HM-48T 48T
EUR 346.8

Human Transfer factor(TF)ELISA Kit
GA-E1749HM-96T 96T
EUR 559.2

Human Transfer factor(TF)ELISA Kit
QY-E00085 96T
EUR 472.8

Human Transfer factor,TF ELISA Kit
YLA1849HU-48T 48T
EUR 435

Human Transfer factor,TF ELISA Kit
YLA1849HU-96T 96T
EUR 562.5

Bovine Glycolipid transfer protein (GLTP)
1-CSB-YP009539BO
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bovine Glycolipid transfer protein(GLTP) expressed in Yeast

Bovine Glycolipid transfer protein (GLTP)
1-CSB-EP009539BO
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bovine Glycolipid transfer protein(GLTP) expressed in E.coli

Transfer Pipette 23.0mL Extra Long 300mm
ARG1840 PK100
EUR 31.6

Transfer Pipette 6mL Extra Long 230mm
ARG1860 PK500
EUR 48.05

T-Pro Transfer Blotting buffer (10X)
JB08-H001 500ml/BT
EUR 162

Human Phospholipid transfer protein (PLTP)
1-CSB-YP018212HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Phospholipid transfer protein(PLTP) expressed in Yeast

Human Phospholipid transfer protein (PLTP)
1-CSB-EP018212HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Phospholipid transfer protein(PLTP) expressed in E.coli

Glycolipid Transfer Protein (GLTP) Protein
20-abx262570
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Glycolipid Transfer Protein (GLTP) Antibody
abx233495-100ug 100 ug
EUR 610.8

Glycolipid Transfer Protein (GLTP) Antibody
20-abx112809
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Glycolipid Transfer Protein (GLTP) Antibody
20-abx128414
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glycolipid Transfer Protein (GLTP) Antibody
20-abx303992
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

TruStrip Sample Transfer Strips, 100-ul, 50/Pk (with sample tracking dye)
STSD-100-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 200-ul, 50/Pk (with sample tracking dye)
STSD-200-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 400-ul, 50/Pk (with sample tracking dye)
STSD-400-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 800-ul, 50/Pk (with sample tracking dye)
STSD-800-50 1 Pk Ask for price

Jumbo Transfer Pipette 10 None Sterile
F87928 PK100
EUR 24.05

Protein Stain Kit for Transfer Membrane
BSP025 10Blots, 10prep
EUR 89.23

ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome)
P402 - Ask for price

Phospholipid Transfer Protein (PLTP) Antibody
20-abx212015
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Phospholipid Transfer Protein (PLTP) Antibody
20-abx142148
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Phospholipid Transfer Protein (PLTP) Antibody
20-abx004303
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Phospholipid Transfer Protein (PLTP) Antibody
20-abx174059
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Phospholipid Transfer Protein (PLTP) Antibody
20-abx174060
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Phospholipid Transfer Protein (PLTP) Antibody
20-abx178016
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

Phospholipid Transfer Protein (PLTP) Antibody
20-abx178017
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Phospholipid Transfer Protein (PLTP) Antibody
20-abx131266
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Phospholipid Transfer Protein (PLTP) Antibody
20-abx131267
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Phospholipid Transfer Protein (PLTP) Antibody
abx146426-100ug 100 ug
EUR 469.2

Phospholipid Transfer Protein (PLTP) Antibody
abx033529-400ul 400 ul
EUR 627.6

Phospholipid Transfer Protein (PLTP) Antibody
abx033529-80l 80 µl
EUR 343.2

Phospholipid transfer protein Antibody / PLTP
RQ6393 100 ug
EUR 356.15
Description: Phospholipid transfer protein (PLTP), also known as lipid transfer protein II is a protein that in humans is encoded by the PLTP gene. This gene is mapped to 20q13.12. The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.

Recombinant Glycolipid Transfer Protein (GLTP)
4-RPC502Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Glycolipid Transfer Protein expressed in: E.coli

TruStrip Sample Transfer Strips, 100-ul, 50/Pk (without sample tracking dye)
STS-100-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 200-ul, 50/Pk (without sample tracking dye)
STS-200-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 400-ul, 50/Pk (without sample tracking dye)
STS-400-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 800-ul, 50/Pk (without sample tracking dye)
STS-800-50 1 Pk Ask for price

Rat Glycolipid Transfer Protein ELISA kit
E02G0192-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glycolipid Transfer Protein ELISA kit
E02G0192-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glycolipid Transfer Protein ELISA kit
E02G0192-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Transfer Pipette 1.2mL General Purpose 64mm
ARG1834 PK500
EUR 35.64

Transfer Pipette 1.7mL General Purpose 87mm
ARG1838 PK500
EUR 35.64

Transfer Pipette 7.5mL Large Bulb Graduated
ARG1864 PK500
EUR 34.8

Pig Glycolipid Transfer Protein ELISA kit
E07G0192-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glycolipid Transfer Protein ELISA kit
E07G0192-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glycolipid Transfer Protein ELISA kit
E07G0192-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glycolipid Transfer Protein ELISA kit
E08G0192-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glycolipid Transfer Protein ELISA kit
E08G0192-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glycolipid Transfer Protein ELISA kit
E08G0192-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glycolipid Transfer Protein ELISA kit
E06G0192-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glycolipid Transfer Protein ELISA kit
E06G0192-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glycolipid Transfer Protein ELISA kit
E06G0192-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Glycolipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Phospholipid Transfer Protein (PLTP)
4-RPC728Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Phospholipid Transfer Protein expressed in: E.coli

Recombinant Phospholipid Transfer Protein (PLTP)
4-RPC728Ra01
  • EUR 562.98
  • EUR 274.80
  • EUR 1781.18
  • EUR 673.73
  • EUR 1227.46
  • EUR 452.40
  • EUR 4272.96
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Phospholipid Transfer Protein expressed in: E.coli

Pig Phospholipid Transfer Protein ELISA kit
E07P0131-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Phospholipid Transfer Protein ELISA kit
E07P0131-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Phospholipid Transfer Protein ELISA kit
E07P0131-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipid Transfer Protein ELISA kit
E08P0131-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipid Transfer Protein ELISA kit
E08P0131-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Phospholipid Transfer Protein ELISA kit
E08P0131-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Phospholipid Transfer Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Primarily based on the outcomes, pDNA (bFGF encoding) complex-loaded hydrogel dispersed with PCL microspheres could also be employed as a bioactive bulking agent for the therapy of glottal insufficiency.

The Rcs stress response inversely controls floor and CRISPR-Cas adaptive immunity to discriminate plasmids and phages

Micro organism harbour a number of innate defences and adaptive CRISPR-Cas methods that present immunity towards bacteriophages and cellular genetic parts. Though some micro organism modulate defences in response to inhabitants density, stress and metabolic state, a scarcity of high-throughput strategies to systematically reveal regulators has hampered efforts to know when and the way immune methods are deployed. We developed a sturdy strategy referred to as SorTn-seq, which mixes saturation transposon mutagenesis, fluorescence-activated cell sorting and deep sequencing to characterize regulatory networks controlling CRISPR-Cas immunity in Serratia sp. ATCC 39006.

We utilized our know-how to evaluate csm gene expression for ~300,000 mutants and uncovered a number of pathways regulating kind III-A CRISPR-Cas expression. Mutation of igaA or mdoG activated the Rcs outer-membrane stress response, eliciting cell-surface-based innate immunity towards various phages through the transcriptional regulators RcsB and RcsA. Activation of this Rcs phosphorelay concomitantly attenuated adaptive immunity by three distinct kind I and III CRISPR-Cas methods.

Rcs-mediated repression of CRISPR-Cas defence enabled elevated acquisition and retention of plasmids. Twin downregulation of cell-surface receptors and adaptive immunity in response to emphasize by the Rcs pathway allows safety from phage an infection with out stopping the uptake of plasmids which will harbour useful traits.

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